Bauhaus-Universität Weimar

Department of Physiological Chemistry, University of Michigan, Medical School
Lewis, Howard B.
ate and specially qualified medical students. The senior 
members of the staff also meet weekly at lunch with cer¬ 
tain members of the related departments of physiology, 
pharmacology, and clinical investigation, at which a 
critical discussion of some subject of general interest is 
presented by each member in turn. 
The second semester of the academic year is devoted 
to research by members of the departmental staff, al¬ 
though investigations are carried out also during the 
first semester, to which the intensive teaching is confined. 
The chief problems under investigation in the depart¬ 
ment may be grouped under four heads. 
1. The intermediary metabolism of the proteins. For 
a number of years the metabolism of cystine and related 
sulphur compounds has been studied. This has led to 
an investigation of the non-protein sulphur compounds 
of the blood. Lack of adequate methods for the estima¬ 
tion of these has made it necessary to develop quanti¬ 
tative micromethods for the determination of the parti¬ 
tion of the various types of sulphur compounds in 
tissues and blood. A comparative study of the rate of 
absorption of certain amino-acids, constituents of the 
protein molecule, from the gastro-intestinal canal, in 
relation to their rate of deamination and their ability 
to serve as precursors of glycogen in the white rat is in 
progress. The study of the intermediary metabolism 
of the aromatic amino-acids, phenylalanine and tyro¬ 
sine, is also being continued. 
2. The chemical changes in the development of the 
embryo with especial reference to nucleic acid and 
3. Purine metabolism. Allantoin. 
4. The relation of the diet to the synthesis of body 
lipids. In this connection, a detailed study of the 
composition of human body fat, in part already pub¬ 
lished, is being undertaken. 
The department has also been ready, as the occasion 
demanded, to cooperate with clinical departments in 
research in which chemical studies outside the field of 
the usual clinical researches are necessitated. As illus¬ 
trations may be cited the cooperative investigations 
with the Department of Dcrmatory and Syphilology on 
the lipids of human skin and on the cholesterol metab¬ 
olism in xanthoma. 
H. B. Lewis, professor of physiological chemistry 
A. A. Christman, assistant professor 
H. C. Eckstein, assistant professsor 
H. 0. Calvery, assistant professor 
Mabel H. Miller, instructor 
R. H. Wilson, assistant 
J. P. Chandler, assistant 
A. White, assistant 
W. T. Krebs, assistant 
S. N. Rowe, assistant 
Sarah Shomer, assistant 
Of these, all members except the assistants, who are 
carrying out work for advanced degrees, are on full 
time. In addition, one full-time technician and store¬ 
keeper, with additional part-time assistance for the care 
of animals, etc., is employed. 
The total yearly budget including salaries, wages, 
equipment, and supplies for the academic year 1928-29 
amounts to $31,600. Approximately 75 per cent of this 
amount is expended for salaries. 
Received for Publication February 2, 1929


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