Bauhaus-Universität Weimar

University of Chicago, Division of Biological Sciences, Department of Physiological Chemistry
Koch, Fred Conrad
a quarter of twelve weeks; distributed in three hours of 
lecture, one hour of recitation, and five hours of labora¬ 
tory work. The first course is practically limited to the 
chemistry of the organic constituents of living matter, 
the carbohydrates, lipins, and. proteins. In the lec¬ 
tures the classic organic chemistry of these compounds 
is emphasized, while the recent advances in the struc¬ 
ture of di- and polysaccharides, and in the physical 
chemistry of proteins are also presented. The labora¬ 
tory work includes studies on the qualitative reactions, 
quantitative analysis, preparation, and identification of 
unknown mixtures of these compounds. The second 
course is called the “Chemistry of Digestion, Metabo¬ 
lism, and Excretion.” The lectures include the subjects 
of pH and hydrogen ions; enzymes; digestion; bacterial 
action in the intestine; metabolism of carbohydrates, 
fats, and proteins; neutrality regulation in the living 
organism; internal secretions; and food requirements for 
nutrition. The laboratory work includes experiments 
on the digestive juices and their enzjanes; quantitative 
determination of nitrogen and phosphorus in organic 
matter; pathological urine analysis; quantitative 
analysis for normal urinary constituents as influenced 
by diet; and the quantitative analysis of blood. Dem¬ 
onstrations are also given on electrometric pH deter¬ 
minations, alkali reserve and pH of blood, and of insulin 
action. In the lecture work in both courses, the student 
is not onljr acquainted with our knowledge in the field, 
but the limitations in our knowledge are particularly 
pointed out and possible research problems indicated. 
Six advanced courses are offered. With the excep¬ 
tion of one on the biochemistry of internal secretions, 
which is a half-major lecture course, these are all major 
courses with the chief emphasis placed on the laboratorjr 
work. They are essentially preresearch courses de¬ 
signed to train the student in the use of special methods 
and apparatus. 
In the course on physicochemical methods applied to 
biochemical problems, which is given with about two 
lectures a week, the student makes determinations of 
freezing points, electric conductivity, surface tension, 
viscosity, pH electrometrically as well as colorimetri- 
cally, oxidation-reduction potentials, polarimetry, spec¬ 
troscopy, and refractometry. In each case the student 
first assures himself of proficiency in the use of the 
apparatus by work on simple systems, and then under¬ 
takes the study of some biological process or system. 
The greatest liberty is allowed suitably trained students 
in the choice of experiments, and each student must 
devise or select some one experiment outside the regular 
Fig. 2.—Students’ Research Laboratory for Physicochemical Work


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