Bauhaus-Universität Weimar

Reports of Visits to Foreign Laboratories, vol. 3 (1913-16) [Illustrated Typoscript in 7 volumes] Reproduced with the kind permission of Dr. Cecil E. Leith
Benedict, Francis Gano
amount of chlorine in blood serum, and found they could wort with an accu¬ 
racy of 0.1 per cent, using 1 c.c. of the solution. I ordered one of 
these titration bulbs for use in the Nutrition Laboratory. 
I also saw in this laboratory a dog treadmill (see figures 43 and 44) 
one of which I secured for our own work with animals. 
Ourare experiments. 
One of the most important objects of my visit to Budapest was to 
obtain more definite information regarding the long series of experiments 
with dogs that Tangl and his co-workers have been making on the effect of 
curare. The artificial ventilation apparatus of Hans Meyer was used (the 
intake of the pump being from outdoors) and the air expired by the cura- 
rized dog was carried through an Elster meter to a Zuntz-Geppert gas analy¬ 
sis apparatus. The dog they were working upon had had the pancreas com¬ 
pletely extirpated 13 days before and had severe diabetes with sugar in 
the urine. No narcotic was used but the animal was tied to the board, 
his neck opened, and a Y-shaped tracheal fistula inserted for artificial 
respiration. One carotid artery was then connected with a blood pressure 
apparatus (a Htfrthle manometer) and the two jugulars used for the injection 
of a sugar solution of hormone in one and of curarine in the other. A 
cannula was arranged for introducing the sugar solution, the curarine being 
injected with a syringe after the dog had been placed in the warm chamber 
designed by Tangl. (See figures 45 and 46.) Graphic records of the blocd. 
pressure were secured on the kymograph, relative values being thus directly 
shown. Tangl uses phosphorus for absorbing the oxygen and says it works 
very well indeed. The carbon dioxide is absorbed in 5 minutes, and the 
oxygen in 10 or 15 minutes, but he still uses the thermo-barometer of Zuntzi 
After the dog is placed in the warm chamber, one half hour is allowed 
to elapse before beginning the first experiment. The rectal


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