Bauhaus-Universität Weimar

Handbook for the Physiological Laboratory. Text
Burdon-Sanderson, John Scott E. Klein Michael Foster T. Lauder Brunton
a rod of whalebone or other suitable implement. In this case 
the fibrin is obtained in fine fibres, which may also be rendered 
white by washing. In a the fibrin has passed through a pre¬ 
vious condition in which it was gelatinous. In b it is obtained 
directly in the fibrillated state. 
4. Some plasma is diluted with one hundred times its volume 
of ice-cold water, or three-quarter per cent, salt solution, and 
allowed to stand. After twenty-four hours, it will be found 
that there are long delicate filaments of fibrin, which stretch 
across the mass of liquid in every direction, from one side 
to the other of the vessel in which it is contained. These 
filaments, the extremities of which adhere to the glass surface, 
are in the highest degree elastic. If they are separated from 
1 their points of attachment, they shrivel up into little lumps of 
fibrin. If these again be drawn out into lengths, they resume 
their original form when let go, as completely as a bit of india- 
l rubber would do. 
I 5. The fibrin prepared in 3 is placed in water containing one 
per thousand of hydrochloric acid. At first it swells out into a 
bulky hyaline mass. If it is then placed in the air bath, and 
kept at a temperature of from 40° to 60° C., it wastes away at a 
rate w7hich varies according to the temperature. In undergoing 
solution the fibrin has been transformed into another albuminous 
compound, syntonin or acid-albumin.# If the liquid is carefully 
neutralized, the syntonin is precipitated, but the precipitate is 
re-dissolved in a slight excess of alkali or alkaline carbonate. 
6. Another portion of the same fibrin is soaked in solution 
of peroxide of hydrogen. It is then placed on a sheet of filter¬ 
ing paper, which has been previously soaked in tincture of 
guaiacum. It soon becomes surrounded with a border of blue, in 
consequence of the oxidation of the guaiacum. Another method 
consists in first steeping a fragment of fibrin in alcohol, then in 
tincture of guaiacum, and finally immersing it in the solution of 
the peroxide : the fibrin becomes blue. The same thing happens 
if the fibrin is dipped in a mixture of the tincture and the solu¬ 
tion. This reaction signifies simply that fibrin decomposes 
peroxide of hydrogen : it affords no proof of the presence of 
4. Experiments relating to the so-called Fibrin Fac¬ 
tors—Paraglobulin and Fibrinogen.—In every act of coagu¬ 
lation, fibrin appears to be produced by the combination of two 
albuminous substances closely allied as regards their chemical 
characters, both of which are to be found in plasma as obtained 
by any of the methods above described. Fifty cubic centimeters 
* The ending in is adopted here and elsewhere to denote that the word is used in 
a stcechiological sense. Albumen is white of egg.


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